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KMID : 0364320150400040001
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Journal of East-West Medicine
2015 Volume.40 No. 4 p.1 ~ p.13
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Capsaicin induces Apoptotic Cell Death in Stomach adenocarcinoma cell
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Kim Bong-Suk
Byun Joon-Seok
Kwon Hae-Won
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Abstract
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Objectives：Apoptosis is a key regulator of tissue homeostsis, which critically depends on the balance between proliferation and cell death.
Methods：Capsaicin induces apoptosis in AGS cells, human stomach adenocarcinoma cell line.
Result：AGS cells showed dose-dependent manner apoptotic cell death. Increased apoptotic cell death, exposured to Capsaicin, resulted from induction of Bad translocation from cytosol to mitochondria, activation of mitochondrial Bax, inhibition of Bcl2, induction of AIF translocation from mitochondria to nuclear, induction of cytochrome-c release from mitochondria to cytosol, activation of caspase and PARP cleavage.
Conclusions：These results suggest that Capsaicin may be potential therapeutic approach in the clinical management of stomach adenocarcinoma.
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KEYWORD
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Capsaicin, AGS Cell, Apoptosis
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